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pentobarbital will lower the extent or outcome of midostaurin by impacting hepatic/intestinal enzyme CYP3A4 metabolism. Prevent or Use Alternate Drug. Solid CYP3A4 inducers may perhaps decrease midostaurin concentrations leading to reduced efficacy.pentobarbital and olopatadine intranasal the two maximize sedation. Avoid or Use Alternate Drug. Coad